Differences in the Immunogenicity of Leukemia L1210 Sublines in DBA/2 Mice1

After the i.p. inoculation of IO3, IO4, or IO5 leukemia L1210 cells, the survival of DBA/2Ha-DD mice was longer than that of DBA/2J or DBA/2Cr mice. This difference was greatly reduced in mice that received total body X-radiation (250 R) the day prior to cell inoculation and in nonirradiated mice after the inoculation of IO6 or IO7 LI210 cells. DBA/2Ha-DD, DBA/2J, and DBA/2Cr mice survived longer after the inoculation of cells from an L1210 line resistant to methylglyoxal-bis(guanylhydrazone) than after inoculation of cells from the parent L1210 line. These differences were also reduced in preirradiated mice. Treatments with low doses of arabinosylcytosine were more effective against the L1210 cells resistant to methylglyoxal-bis(guanylhydrazone) than against the parent line in both DBA/2Ha-DD and DBA/2J mice; similar differences in therapeutic response were seen in DBA/2Ha-DD mice treated with 4,4'-diacetyldiphenylurea-bis(guanylhydrazone), 2-chloro-4',4"-di-2-imidazolin-2-ylterephthalanilide, or